A

 

Alkoliklerin nöropsikiyatrik sendromları

(Wernicke-Korsakoff sendromu)

Nedenler:

B1 (tiamin) eksikliği: kronik alkolizm, ödünsüz açlık grevleri, kronik malnütrisyon, GİS operasyonları

 

3 temel bulgu:

  • Konfüzyon ya da amnezi

  • Nistagmus ya da oftalmopleji

  • Ataksi

 

Ek bulgular:

Öğrenme güçlüğü

Çift görme

Strabismus

Apati

Konfabülasyon

Ajistasyon

Halüsinasyon

 

  • Sutherland GT, Sheedy D, Kril JJ. Neuropathology of alcoholism. Handbook of Clinical Neurology, 125:603-615, 2014

  • Wijnia JW, Oudman E, Bresser EL, Gerridzen IJ, van de Wiel A, Beuman C, Mulder CL. Need for early diagnosis of mental and mobility changes in Wernicke encephalopathy. Cognitive & Behavioral Neurology, 27(4):215-221, 2014

  • Scalzo SJ, Bowden SC, Ambrose ML, et al. Wernicke-Korsakoff syndrome not related to alcohol use: a systematic review. Journal of Neurology,  Neurosurgery & Psychiatry, 86(12):1362-1368, 2015

  • Oudman E, Van der Stigchel S, Nijboer TC, Wijnia JW, Seekles ML, Postma A. Route learning in Korsakoff's syndrome: Residual acquisition of spatial memory despite profound amnesia. Journal of Neuropsychology, 10(1):90-103, 2016

  • Isenberg-Grzeda E, Rahane S, DeRosa AP, et al. Wernicke-Korsakoff syndrome in patients with cancer: a systematic review. Lancet Oncology, 17(4):e142-148, 2016