E

 

Epidermolysis bullosa acquisita

Edinsel

Orta yaşlarda belirir

Kronik otoimmun hastalık

Neden: Tip VII kollagene karşı otoantikorlar

Deri kırılgan

Mukozalar kırılgan

En küçük travmalarda deri ve mukozaları etkileyen büller

Büllerin iyileşmesinde sikatris oluşumu

  • Generalize tip

Kırmızı-kaşıntılı plaklar

Alevlenme atakları

Ölümcül olabilir

  • Mukozalara özgü tip

Ağız mukozasında veziküller/büller

Veziküller/büller: özofagus, konjunktiva, rektum, vagina

 

  • Kasperkiewicz M, Sadik CD, Bieber K, et al. Epidermolysis Bullosa Acquisita: from pathophysiology to novel therapeutic options. Journal of Investigative Dermatology, 136(1):24-33, 2016

  • Kim M, Borradori L, Murrell DF. Autoimmune blistering diseases in the elderly: Clinical presentations and management. Drugs & Aging, 33(10):711-723, 2016

  • Asfour L, Chong H, Mee J, et al. Epidermolysis Bullosa Acquisita (Brunsting-Perry Pemphigoid Variant) Localized to the face and diagnosed with antigen identification using skin deficient in Type VII Collagen. American Journal of Dermatopathology, 39(7):e90-e96, 2017

  • Wick MR. Bullous, pseudobullous, & pustular dermatoses. Seminars in Diagnostic Pathology, 34(3):250-260, 2017

  • Vorobyev A, Ludwig RJ, Schmidt E. Clinical features and diagnosis of epidermolysis bullosa acquisita. Expert Review of Clinical Immunology, 13(2):157-169, 2017