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Levy-Jeghers sendromu (intestinal polyposis)

Kalıtsal - AD

İnce bağırsaklarda Peutz-Jeghers sendromu-tipi multipl hamartomatöz polipler

Poliplerin yol açtığı ileus

İnce bağırsak poliplerinden kanama (demir eksikliği ane­misi)

Mesane, nazofarinks, bronş polipleri

Hiperpigmentasyon (parmaklarda, perioral, periorbital, perianal)

Dudaklarda pigmentasyon

Yanak mukozasında pigmentasyon

Periodontal patolojiler

Kalın bağırsak poliplerinde (varsa) kanserleşme

Çeşitli polipöz oluşumlar (burun, uterus, mesane, vd)

Erkeklerde östrojen üreten Sertoli hücreli tümöre bağlı jinekomasti

Bronş adenomu

Kanser riski (mide, pankreas, meme, uterus, ovaryum)

Bkz Peutz-Jeghers sendromu

 

  • Brinster DR, Raper SE. Synchronous colon and pancreatic cancers in a patient with Peutz-Jeghers syndrome: report of a case and review of the literature. Surgery, 135(3):352-354, 2004

  • Hearle N, Schumacher V, Menko FH, et al. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clinical Cancer Research, 12(10):3209-3215, 2006

  • Kopacova M, Tacheci I, Rejchrt S, Bures J. Peutz-Jeghers syndrome: diagnostic and therapeutic approach. World Journal of Gastroenterology, 15(43):5397-5408, 2009

  • Beggs AD, Latchford AR, Vasen HF, et al. Peutz-Jeghers syndrome: a systematic review and recommendations for management. Gut, 59:975–986, 2010

  • van Lier MG, Wagner A, Mathus-Vliegen EMH, et al. High cancer risk in Peutz-Jeghers syndrome: a systematic review and surveillance recommendations. The American Journal of Gastroenterology, 105:1258–1264, 2010

  • Haritha A, Jayakumar A. Syndromes as they relate to periodontal disease. Periodontology 2000, 56:65–86, 2011