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Myelodisplastik sendromlar

Genlerdeki somatik mutasyon kökenli

Klonal hematopoietik kök hücre bozuklukları

İleri yaşlarda ortaya çıkar

Hematopoiezis yetersiz

Periperik sitopeniler (nötropeni, lenfositpeni, trombositopeni, anemi)

Dişeti kanamaları

GİS kanamaları

Purpura/ekimoz türü kanamalar

İnfeksiyon riski yüksek

AML riski yüksek

Otoimmun hastalıklar

Vaskülitik patolojiler

 

• Hyjek E, Vardiman JW. Myelodysplastic/myeloproliferative neoplasms. Seminars in Diagnostic Pathology, 28(4):283-297, 2011

• Hahn CN, Chong C-E, Carmichael CL, et al. Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. Nature Genetics, 43: 1012-1017, 2011

• Yu QH, Wang SY, Wu Z. Advances in genetic studies of inherited bone marrow failure syndromes and their associated malignancies. Translational Pediatrics, 3(4):305-309, 2014

• Ortmann CA, Kent DG, Nangalia J, et al. Effect of mutation order on myeloproliferative neoplasms. New England Journal of Medicine, 372: 601-612, 2015

• Clara JA, Sallman DA, Padron E. Clinical management of myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes. Cancer Biology & Medicine, 13(3):360-372, 2016

• Radsak M, Platzbecker U, Schmidt CS, et al.  Infectious complications in patients with myelodysplastic syndromes: A review of the literature with emphasis on patients treated with 5-azacitidine. European Journal of Haematology, 99(2):112-118, 2017

• Savage SA, Dufour C. Classical inherited bone marrow failure syndromes with high risk for myelodysplastic syndrome and acute myelogenous leukemia. Seminars in Hematology, 54(2):105-114, 2017

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