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Trombositopeni integrin, Beta-3

Kalıtsal - AD/AR

Burun kanamaları

Dişeti kanamaları

GIS kanamaları

Deride purpuralar ve ekimozlar

Menoraji

Beyin kanamaları

Trombosit sayısı normal

Trombosit nitelik bozukluğu (kümeleşme ve pıhtılaşma defekti)

  • Bajt ML, Ginsberg MH, Frelinger AL III, et al. A spontaneous mutation of integrin alpha(IIb)-beta(3) (platelet glycoprotein IIb-IIIa) helps define a ligand binding site. Journal of Biological Chemistry, 267: 3789-3794, 1992

  • Thornton MA, Poncz M, Korostishevsky M, et al. The human platelet alpha-IIb gene is not closely linked to its integrin partner beta-3. Blood, 94: 2039-2047, 1999

  • Xiao T, Takagi J, Coller BS, et al. Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature, 432: 59-67, 2004