Z

 

Zollinger-Ellison sendromu (gastrin hipersekresyonu)

Kalıtsal - AD

MEN1 sendromunun bulgularından

Duodenum mukozasında Gastrinoma varlığında: peptik ülser (+diyare olabilir)

Pankreasta insülinoma varlığında: hipoglisemi atakları

Pankreasta glukagonoma varlığında: hiperglisemi, anemi, diyare, venöz tromboz, deri döküntüleri (necrolytic migratory erythema)

Bağırsakta VIPoma varlığında: sulu diyare, hipokalemi, aklorhidri

 

  • Jensen RT. Pancreatic endocrine tumors: recent advances. Annals of Oncology, 10 Suppl 4:170–176, 1999

  • Marx SJ. Multiple endocrine neoplasia type 1. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. 8 ed., pp. 943-966, Mcgraw-Hill, New York, 2001

  • Gibril F, Schumann M, Pace A, Jensen RT. Multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome: a prospective study of 107 cases and comparison with 1009 cases from the literature. Medicine (Baltimore), 83:43–83, 2004

  • DeLellis RA, Lloyd RV, Heitz PU, Eng C. Pathology and Genetics: Tumours of the Endocrine Organs. World Health Organization Classification of Tumours Series. Vol 8. IARC Press; Lyon-France, 2004

  • Klöppel G, Perren A, Heitz PU. The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification. The Annals of the New York Academy of Sciences, 1014:13–27, 2004

  • Hoffmann KM, Furukawa M, Jensen RT. Duodenal neuroendocrine tumors: Classification, functional syndromes, diagnosis and medical treatment.  Best Practice & Research Clinical Gastroenterology, 19:675–697, 2005